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Merck KGaA
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Image Search Results
Journal: Microorganisms
Article Title: An Analysis of the Gut Microbiota and Related Metabolites following PCSK9 Inhibition in Statin-Treated Patients with Elevated Levels of Lipoprotein(a)
doi: 10.3390/microorganisms12010170
Figure Lengend Snippet: ( A – C ) Boxplots representing the concentration (log10 transformed) of total bile acids ( A ), and primary ( B ) and secondary ( C ) bile acids in fecal samples collected at baseline and on treatment. Samples from the same patient are connected using straight lines. The following primary bile acids were detected in feces: cholic acid, taurocholic acid, chenodeoxycholic acid, taurochenodeoxycholic acid and glycochenodeoxycholic acid. The following secondary bile acids were detected in feces: deoxycholic acid, lithocholic acid, ursodeoxycholic acid, taurolithocholic acid, tauroursodeoxycholic acid, taurodeoxycholic acid and glycodeoxycholic acid. For statistical inference, we used a paired t -test, and the corresponding p -values are shown in each graph. ( D ) Linear relationship between the reduction in plasma LDL-c and the concentration of fecal bile acids (log10 transformed) after alirocumab therapy. Line of best fit for the linear model is plotted with 95% confidence interval (grey shade area). Individual samples are represented with black dots. The regression coefficient, coefficient of determination and the result of the F-test for the linear model are shown on the top of the plot.
Article Snippet: For identification of the different classes of BAs, we used the following pure standards to create a mass spectral–retention time library; taurocholic acid (Santa Cruz, sc220189, Dallas, TX, USA), taurolithocholic acid (Cayman Chemicals, 17275, Ann Arbor, MI, USA), taurochenodeoxycholic acid (Steraloids, C1162-000, Newport, RI, USA), tauroursodeoxycholic acid (Steraloids, C1052-000), glycolithocholic acid (Steraloids, C1435-000),
Techniques: Concentration Assay, Transformation Assay, Clinical Proteomics